Pharmaceutical and food ingredients
Pharmaceutical and food ingredients - PEG modifier
PEG modifier
NOF Corporation has developed a high-quality polyethylene glycol (PEG) modifier-SUNBRIGHT® series and a monodisperse PEG derivative-PUREBRIGHT® series that are ideal for the preparation of bioactive substances such as pharmaceuticals and proteins.
The SUNBRIGHT® series and PUREBRIGHT® series are extremely pure and diverse functional group PEGs and are the most suitable DDS bases for PEG modification of drugs. By using PEG modifiers with various functional groups at the ends, it is possible to introduce PEG chains into drugs, enzymes, phospholipids, and other biological substances. In addition, by binding a hydrophobic polymer or the like with a PEG modifier, a polymer micelle can be formed and the hydrophobic drug or the like can be stably dispersed in an aqueous solution. In recent years, monodisperse PEG has been used especially as a linker for antibody drug conjugates (ADCs) for the purpose of improving hydrophilicity. As described above, by modifying PEG, it is possible to stabilize the drug or the like, reduce the antigenicity, reduce the dose, etc., and further enhance the targeting property by binding the antibody or the like to the surface. I can do it.
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